• Find novel targets, determine activities of kinase inhibitor drugs or novel food ingredients and elucidate their mechanisms of action.
• Pathway elucidation.
• Determine the mode of action of pharmacological compounds.
• Perform target interaction/ engagement studies.
• Enzymatic characterization of novel or mutated kinases.
• Identification of substrates for novel, mutated or post-translationally modified kinases.
• Biomarker classification in clinical samples using kinome signatures.
• Development of prognostic biomarkers to assess disease progression or risk of recurrence in the clinic.
• Identification of pharmacodynamic biomarkers to evaluate drug dose or combination therapy.